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Hours unless otherwise indicated. The cells were not preincubated in DMEM containing LPDS before the experiments, as we have previously shown that such treatment has no influence on the results obtained.16 Monoclonal antibodies directed against apoE and apoB were generously provided by Drs Ross Milne and Yves Marcel of the Clinical Research Institute of Montreal. Two anti-apoE antibodies were used: 1D7, an antibody that specifically inhibits binding by apoE to the apoB E LDL ; receptor, and 6C5, an antibody that reacts with an epitope that is not involved with receptor recognition.30 The anti-apoB antibodies used were 5E11, an antibody that specifically inhibits the binding of apoB to the apo B E LDL ; receptor, and 1D1, an antibody that reacts with an epitope that is not involved with receptor recognition.31 Antibodies were affinity purified from ascitic fluid and Fab fragments prepared as described previously.32 Fab fragments were incubated with VLDL preparations for 0.5 hour at 37C before addition to cells. Determination of Cellular Lipid Content Cellular lipid analyses were carried out by using modifications to methods described previously.16 Cells were washed twice with buffer B 0.15 mol L NaCl, 50 mmol L Tris, and 0.2% bovine serum albumin [BSA], pH 7.4 ; and twice with buffer B without BSA. Lipids were extracted in situ using two 30-minute incubations with 1.0 mL hexane isopropanol 3: 2, vol vol ; . The remaining cells were digested for 16 hours at room temperature in 1.0 mL of 0.1N NaOH, and cell protein was determined.22 The lipid extracts were pooled and dried under nitrogen, resuspended in chloroform methanol 2: 1, vol vol ; , and separated by thin-layer chromatography TLC ; with petroleum ether diethyl ether acetic acid 84: 15: 1, vol vol vol ; . Free cholesterol, esterified cholesterol, and trigryceride spots were identified after exposure to iodine ; and eluted from the TLC gel with isopropanol. Recovery was assessed by using [la, 2a n ; -3H]cholesteryl oleate and grycerol tri[l-MC]oleate Amersham, Oakville, Ontario ; . To each cholesteryl ester and free cholesterol sample, 5a-cholestane was added as an internal standard, the samples were saponified, and the mass of cholesterol was determined by gas-liquid chromatography. The triglyceride sample was adjusted to 1.0 mL with isopropanol, and the mass was determined by using the method of Neri and Frings.33.
From page 6 it didn't have to be rushed. "I would much rather see this than tags, for sure. They just look gross." Tags are identifying signature symbols or letters used by graffiti vandals. Danley said: "Heaps of my mates got caught for heaps of graffiti." Instead the teenagers learnt from an urban artist about the history of spray painting and the different methods and nozzles for getting the right effects. Elliot, who designed a gingerbread man dancing to loudspeakers, said: "I learnt I was good at art, because I failed it at school. "Spray paint is fun, it's heaps different to school art even though you get more choice." Victoria said she wanted a career in art, probably as a graphic designer for clothing. Young people interested in future projects should ring Catherine Stubbs, Mosman Park's community development officer, on 9384 1633.
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This update is based on a rigorous analysis of the available data, including consultation with leading experts to ensure that we had the most informed understanding possible with respect to hepatic and myasthenia gravis adverse events. Based on the in-depth review of the clinical trial and postmarketing data, we continue to believe that the benefits of Ketek outweigh the risks when the drug is used as directed for its approved indications."said Sol Rajfer MD, President of U.S. Science and Medical Affairs at sanofi-aventis U.S. Over the past 10 years infectious disease experts and medical societies throughout the world have expressed the need for new compounds active against antibiotic drug resistant S. pneumoniae. Ketek is effective and safe when used as directed for its approved indications in the treatment of acute bacterial exacerbation of chronic bronchitis AECB ; , acute bacterial sinusitis ABS ; , and mild to moderate community-acquired pneumonia CAP ; caused by susceptible pathogens. Significantly, Ketek is indicated for the treatment of mild to moderate CAP caused by multi-drug resistant S. pneumoniae. Earlier this month, sanofi-aventis voluntarily paused enrollment of its Ketek pediatric clinical trials. This pause is to allow the company to confirm that the current program remains consistent with the FDA'current thinking on the design of pediatric trials. It is important to note that no safety reason has s been identified to warrant the pause in the enrollment of the pediatric clinical trials. Ketek has been available in the U.S. since 2004 where sales in the first half of 2006 are estimated to be 50 million dollars. For more precise information regarding the update to the Ketek prescribing information in the U.S., please visit the Web site Ketek or the FDA Web site.
Access to this information, and until we get a free and open dialogue within the scientific community, I don't think, for one, I will ever be satisfied that there isn't some data suggesting that some children may have serious side effects from some of these vaccines that is really going undetected, unnoticed, and yes, it may actually cause autism. Let me just conclude by saying that.
28. Had any application for health or life insurance revoked, declined, deferred, postponed, or restricted in any way?.
Tation 1986; 42: 515-17 Ghalie R, Szidon J, Thompson L, et al. Evaluation of pulmonary complications after bone marrow transplantation: the role of pretransplant pulmonary function tests. Bone Marrow Transplant 1992; 10: 359-65 Selker RG, Jacobs SA, Moore PB, et al. 1, 3-bis 2-chloroethyl ; 1-nitrosurea BCNU ; -induced pulmonary fibrosis. Neurosurgery 1980; 7: 560-65 Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Rev Respir Dis 1981; 123: 659-64 American Thoracic Society. Single breath carbon monoxide diffusing capacity transfer factor ; : recommendations for a standard technique. Rev Respir Dis 1987; 136: 1299-1307 Burrows B, Kasik JE, Niden AH, et al. Clinical usefulness of the single breath diffusing capacity test. Rev Respir Dis 1961; 84: 789-806 Cotes JE. Lung function. 4th ed. London: Blackwell Scientific Publications, 1979; 225-50 19 Aronin PA, Mahaley MS Jr, Rudnick SA, et al. Prediction of BCNU pulmonary toxicity in patients with malignant gliomas: an assessment of risk factors. N Engl J Med 1980; 303: 183-88 Philip T, Armitage JO, Spitzer G, et al. High-dose therapy and autologus bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphomas. N Engl J Med 1987; 316: 1493-98 Petersen FB, Appelbaum FR, Hill R, et al. Autologus marrow transplantation for malignant lymphoma: a report of 101 cases from Seattle. J Clin Oncol 1990; 8: 638-47 and ketoprofen.
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Espiratory infections can be treated with a new antibiotic, we hear from Paul Iannini, MD. Telithromycin Ketek ; is a recently approved antibiotic that is believed not to contribute to antibiotic resistance. Bacteria develop resistance to antibiotics that are routinely used over a period of time. Telithromycin, which is as effective as other antibiotics, can be used to treat bronchitis, sinusitis and pneumonia. Caution: Telithromycin should not be taken with cholesterollowering statins, such as simvastatin Zocor ; and lovastatin Mevacor.
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The basic form of the Silicon Drift Detector SDD ; was proposed in 1983 by Gatti and Rehak. Intensive further development by Josef Kemmer and others improved this concept and led to a commercially available product in 1998, manufactured by his company KETEK for FAST ComTec. The detector consists of a volume of fully depleted silicon in which a strong component parallel to the surface of the electric field "drifts" signal electrons towards a small sized collecting anode. As shown in the schematic drawing below, one side of the detector is covered by a number of increasingly reverse biased field rings generating the drift field. The radiation entrance side is the non structured p + -junction denoted in the figure as back contact, giving a homogeneous sensitivity over the whole detector area. As the device is fully depleted the total thickness of 0.45 mm is sensitive to the absorption of X-rays and klonopin.
Grossman, R.A., Edelman, R., and Gould, D.J.: Study of Japanese Encephalitis in Chiangmai Valley, Thailand. VI. Summaryand Conclusions. Amer. J. Epidemiol. 100: 69-- 76, Grossman, R.A. , Benenson, M.W., Scott, R.M., Snitbhan, R., Top, F.H., Jr., and Pantuwatana, S.: An Epidemiological Study of Hepatitis B Virus in Bangkok, Thailand. Am. J., Epidemiol. 101: 144-159, 1975. Hall, A.P., Doberstyn, E.B., Na -Nakorn, Clindamycin. Brit. Med. J., 2: 12-14, 1975. A., and Sonkom, P.: Falciparum Malaria Semi-resistant to.
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Vention. Knopp et al28, 29 found a decreased LDL cholesterol response to a low-fat diet in subjects with markers of insulin resistance. In another study, a reduced cholesterol intake from eggs resulted in larger serum cholesterol decrease in subjects with low body mass index and high HDL cholesterol, likely associated with high insulin sensitivity.30 There are also contradictory findings, as administration of 2 eggs d resulted in a higher increase in LDL cholesterol in subjects with combined hyperlipidemia than in subjects with simple hypercholesterolemia.31, 32 The study by Knopp and co-workers33 in this issue of the Journal has attempted to address some of these apparent discrepancies. The authors tested whether insulin resistance with and without obesity influenced the response in LDL cholesterol levels to egg feeding. By utilizing a randomized, double-blind, placebo-controlled, crossover design, 0, 2 and 4 egg yolks d were given to 197 subjects, divided in three groups, insulin-sensitive, insulinresistant, and obese insulin-resistant. Among insulin-resistant subjects, baseline LDL cholesterol levels were increased. The most pronounced plasma lipoprotein response to the addition of egg yolks was found among lean, insulin-sensitive subjects, with a higher increase in LDL cholesterol levels than for insulin-resistant subjects. Notably, a majority of the study subjects were women, and as insulin-resistant subjects were significantly older than the insulin-sensitive group, it is possible that menopausal state and or hormone replacement therapy may have had an impact on the results. However, the findings are supportive of other studies suggesting decreased cholesterol absorption in the metabolic syndrome. Although no definitive answers are available regarding underlying mechanisms and many possibilities exist, it should be emphasized that cholesterol absorption and synthesis represents two important, interrelated regulatory mechanisms in cholesterol homeostasis, and both are affected by overall diet.16 Changes in one of the pathways may result in compensatory changes in the other, such as an increase in hepatic cholesterol synthesis observed during selective inhibition of cholesterol absorption.34 Further, inhibition of both these pathways by combination of statins, cholesterol synthesis inhibitors, and the recently available cholesterol absorption blocker ezetimibe, has proven synergistic in reducing LDL cholesterol levels.34 37 In addition, other so far relatively unexplored possibilities including genetic variability in cholesterol absorption may play a role. Sehayek et al38 demonstrated a large variability in cholesterol absorption in response to dietary fat changes, and further, during high-fat diets, dietary cholesterol mass absorption varied markedly in response to dietary cholesterol intake. The authors suggested that genetically determined differences between individuals in the regulation of cholesterol absorption might be contributory. While many studies have focused on cholesterol synthesis, plasma lipoprotein metabolism, and the interrelationship between bile acid and cholesterol metabolism, intestinal cholesterol absorption has been a relatively understudied area. Studies to date have demonstrated a considerable variability in cholesterol absorption in response to changes in dietary cholesterol intake. Additional studies are needed to explore underlying mechanisms and whether these observations will translate into more individualized diet recommen and kytril.
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| Ketek rebatesHigh risk any of the following ; More than 35 years old More than 4 weeks to CR WBC count above 30 B lineage ; WBC count above 100 T lineage ; 109 L 109 L Standard risk all of the following ; Less than 35 years old Less than 4 weeks to CR WBC count below 30 B lineage ; WBC count below 100 T lineage ; 109 L Figure 2. Overall survival for all patients. A ; This study. B ; Ph status. 109 L.
You will need to discuss the benefits and risks of using ketek while you are pregnant and lactulose.
Covered Drugs by Category ifosfamide . 34 IFOSFAMIDE MESNA KIT. 34 imipramine hcl . 31 imipramine pamoate . 31 IMOVAX RABIES VACCINE . 65 indapamide. 52 indomethacin . 19 INFANRIX VACCINE VIAL 65 INFERGEN. 64 inpersol-lm with 1.5% dextrose . 75 INSULIN SYRINGES. 45 INTAL INHALER . 72 intralipid. 67 INTRALIPID 30% INTRAVENOUS FAT EMULSION . 67 INTRON A 10 MILLION UNITS INJECTION PEN. 35 INTRON A 10 MILLION UNITS VIAL. 35 INTRON A 10 MILLION UNITS ML KIT . 35 INTRON A 10 MILLION UNITS ML VIAL. 35 INTRON A 18 MILLION UNITS VIAL. 35 INTRON A 3 MILLION UNITS INJECT PEN. 35 INTRON A 5 MILLION UNITS INJECT PEN. 35 INTRON A 50 MILLION UNITS VIAL. 35 INTRON A 6 MILLION UNITS ML VIAL. 35 INVANZ 1 GM VIAL. 27 INVEGA . 39 INVIRASE. 41 IOPIDINE . 68 IPOL VIAL . 65 ipratropium 0.03% spray. 68 ipratropium 0.06% spray. 68 ipratropium bromide 0.02% solution. 72 IRESSA 250 MG TABLET . 36 isonarif capsule. 29 9 isoniazid 100 mg tablet .29 isoniazid 100 mg ml vial .29 isoniazid 300 mg tablet .29 isoniazid 50 mg 5 ml syrup .29 isosorbide dinitrate 10 mg tablet .51 isosorbide dinitrate 2.5 mg tablet sublingual.51 isosorbide dinitrate 20 mg tablet .51 isosorbide dinitrate 30 mg tablet .51 isosorbide dinitrate 40 mg tablet sustained action.51 isosorbide dinitrate 5 mg tablet51 isosorbide dinitrate 5 mg tablet sublingual.51 isosorbide mononitrate .51 isotonic gentamicin 60 mg 100 ml .23 isotonic gentamicin 80 mg 50 ml .23 ISTALOL 0.5% EYE DROPS.68 itraconazole 100 mg capsule .33 J jantoven .45 JANUMET .42 JANUVIA.42 JE-VAX VACCINE.65 jolivette tablet .60 junel.60 junel fe.60 K KALETRA .41 kanamycin 1 gm 3 vial .23 kaon-cl 10 meq tablet sustained action .77 kelnor 1 35 28 tablet .60 KEMADRIN 5 MG TABLET.38 KEPPRA 100 MG ML ORAL SOLUTION .30 KEPPRA 250 MG TABLET .30 KEPPRA 500 MG TABLET .30 KEPPRA 500 MG 5 ML VIAL .30 KEPPRA 750 MG TABLET. 30 KETEK . 28 KETEK PAK 400 MG TABLET . 28 ketoconazole 2% cream . 54 ketoconazole 2% shampoo. 54 ketoconazole 200 mg tablet. 33 ketoprofen . 19 ketorolac 10 mg tablet . 19 ketorolac 15 mg ml vial . 19 ketorolac 30 mg ml vial . 19 ketotifen fumarate 0.025% eye drops. 68 KINERET 100 MG 0.67 ML SYRINGE . 67 klor-con 10 meq tablet . 77 klor-con 8 meq tablet. 77 klor-con m10 tablet. 77 klor-con m20 tablet. 77 klotrix 10 meq tablet sustained action. 77 kuric 2% cream. 54 L labetalol hcl 100 mg tablet. 48 labetalol hcl 200 mg tablet. 48 labetalol hcl 300 mg tablet. 48 labetalol hcl 5 mg ml vial . 48 LACTATED RINGERS INJECTION . 75 LACTATED RINGERS IRRIGATION. 76 lactulose 10 gm 15 solution59 LAMICTAL . 30 LAMICTAL TABLET START KIT BLUE ; . 30 LAMISIL 250 MG TABLET. 33 lamotrigine . 30 LANTUS. 43 leflunomide . 22 leucovorin calcium 10 mg tablet . 35 leucovorin calcium 10 mg ml vial . 35 leucovorin calcium 100 mg vial . 35.
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FIG. 7. Electron micrographs showing the localization of poloxamer407-coated latex nanospheres 150 nm ; in sections through sinusoidal endothelial cells of male New Zealand White rabbits. The poloxamer was supplied by Ugine Kuhlman Company Manchester, UK ; and used as received. Particles 4.0 mg ; were injected intravenously via the marginal ear vein. Bone marrow was extracted from a femoral bone and fixed by an immersion technique Porter et al., 1992b ; . Poloxamer-coated nanoparticles are present in large vesicles designated as dense bodies arrowheads ; . The endothelium of other bone marrow vessels remained indifferent to the presence of poloxamer-407-coated beads. In animals that received uncoated polystyrene particles, the sinus endothelial cells in bone marrow rarely participated in particle uptake from the blood. Micrographs courtesy of Dr. S. M. Moghimi. Bar 1 m and lantus.
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Tina Sommer is the Chairman of International Affairs of the Federation of Small Businesses in the UK and President of the European Small Business Alliance which represents the interest of small business organisations on a pan-European level. She has served in that organisation as an activist for 10 years holding portfolios such as Trade and Industry and Vice Chairman of Welsh Policy. Her background is that of small businesses with the entire family running small businesses in various industries and countries. Tina is a director of Froben Ltd., a consultancy specialising in Administration Analysis and IT. Her work is carried out in a variety of industries such as Manufacturing, Engineering, Catering, Tourism, Timber Industry and Retail. She has worked in countries such as the Baltic States, United Arab Emirates, South Africa and a number of EU States. Four years ago she graduated at the University of Glamorgan, Wales, with an Honours Degree in Enterprise. Her commitment lies with improving the environment for small and medium size businesses whilst running her own business and keeping in close touch with other businesses to identify issues and problems and lavender!
London, 30 March 2007 Doc. Ref. EMEA 140996 2007 QUESTIONS AND ANSWERS ON THE REVIEW OF KETEK TELITHROMYCIN ; As part of its continuous monitoring of medicines, the European Medicines Agency EMEA ; has reviewed the available information on the safety and effectiveness of Ketek telithromycin ; . It has concluded that the ways in which Ketek can be used must be restricted, that some of the warnings in the medicine's prescribing information must be strengthened, and that patients with myasthenia gravis a disease of the nerves causing muscle weakness ; should not be given the medicine. What is Ketek? Ketek contains the active substance telithromycin. Telithromycin is an antibiotic that belongs to the class called the `ketolides', which kill bacteria by stopping them making proteins. Ketek is used to treat adult patients with the following infections: community-acquired pneumonia an infection of the lungs that is caught outside of hospital ; , acute exacerbation flare-up ; of chronic bronchitis long-lasting inflammation of the airways in the lungs ; , acute sinusitis short-lived infection of the sinuses, air-filled passageways in the bones around the nose and eyes ; . Ketek is also used to treat patients aged 12 years or over who have tonsillitis or pharyngitis infections of the tonsils or throat ; caused by the bacterium Streptococcus pyogenes. Ketek is used when a class of antibiotics called `beta-lactams' are not appropriate. Beta-lactams include penicillin, ampicillin and amoxicillin. Ketek is authorised in the European Union European Economic Area, and is marketed in Austria, Belgium, Cyprus, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Malta, Norway, Portugal, Slovenia, Spain, Sweden and the United Kingdom. Telithromycin is also authorised as Levviax, but this product is not marketed in the European Union. Why has the EMEA reviewed the medicine? The EMEA has been carrying out a comprehensive review of the safety and effectiveness of Ketek since January 2006, following reports of severe liver side effects in patients taking telithromycin. As part of this review, several updates relating to the safety of Ketek were made to the Product Information during 2006. These included strengthening the warnings on serious liver reactions and contraindicating the use of the medicine in patients with a previous history of serious liver disorders. In January 2007, the Agency's Committee for Medicinal Products for Human Use CHMP ; requested updated information from the company that makes Ketek on the safety and effectiveness of the medicine in each of its approved indications listed above ; . The review of this information was finalised at the CHMP's meeting of 19-22 March 2007 1 . Which data has the CHMP reviewed? The review included information on the safety and effectiveness of Ketek in each of its approved indications, as well as a comparison of the medicine's balance of benefits and risks with those of other antibiotic medicines that are used to treat infections of the respiratory tract lungs and airways ; . The.
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Cotyle, the neural canal is triangular and capped by a prominent zygosphene. The zygosphene is tall, with large, high-angled articular facets. Medially, a pronounced, rounded tuberosity is present on the anterior face of the zygosphene along the dorsal margin of the neural canal. Lateral to the cotyle, the prezygapophyses are low-slung and dorsoventrally thin. In dorsal view Figure 2A.2 ; , the interzygapophyseal ridge possesses a straight lateral margin that is posteromedially angled between the preand postzygapophyses. The posterior median notch of the neural arch is deep with straight margins, exposing the posteromedial margins of the zygantral articular facets in dorsal view. The prezygapophyseal articular facets are ovate, with straight, transversely oriented anterior margins. Small, pointed accessory processes are visible at the anterolateral margins of the prezygapophyses. In ventral view Figure 2A.3 ; , the centrum is wide with a thin, poorly defined haemal keel in all specimens. In vertebrae from the anterior section of the vertebral column, the hypapophysis originates just anterior to the cotyle. Hypapophyses are robust and ovoid in cross section. The synapophyses are moderately developed, with robust, laterally oriented parapophyses and smaller, posteromedially oriented diapophyses. In vertebrae from the posterior region of the precloacal column, the paralymphatic channels and subcentral paralymphatic fossae are well developed and deeply excavated into the ventral surface Figure 2B.2 ; . In lateral view Figure 2A.4 ; , the interzygapophyseal ridge possesses swollen lateral margins, and is elevated between the pre- and postzygapophyses. In posterior view Figure 2A.5 ; , the lateral margins of the neural arch are strongly sigmoid in outline. The posterior surface of the arch at the level of the zygantrum is rugose and pitted for attachment of intervertebral ligaments. The zygantrum is deep, with a prominent medial ridge. Discussion. The following character combination diagnoses referred specimens to Pythoninae: zygapophyseal bridge straight and posteromedially angled; triangular neural canal; presence of a zygosphenal tuberosity; absence of paracotylar foramina. Individually, none of these characters are unique to pythonines see discussions in Kluge 1988; Szyndlar and Rage 2003 ; , but their combined presence is unique to the lineage. Hoffstetter 1964 ; recognized Python from the Siwalik Group based on a single specimen. Generic assignment was based on overall similarity with extant Python, and Hoffstetter 1964 ; recognized a specific-level distinction based on the following characters: rela and lenalidomide.
1st dam WAJNA, by Nureyev. Winner in 4 starts at 2 and 3 in England, Foster's Silver Cup S., 3rd Shadwell Stud Cheshire Oaks, Lonsdale S. Dam of 8 foals of racing age, including a 2-year-old of 2005, seven to race, 4 winners, including-STATE CITY c. by Carson City ; . 6 wins in 12 starts to 4 in U.A.E., Dubai Golden Shaheen [G1], Jebel Ali Sprint, 3rd U.A.E. Two Thousand Guineas [G3]; placed at 4, , 381 in N.A., 3rd Tom Fool H. [G2]. 2nd dam WIND SPIRIT, by Round Table. 3 wins at 2 and 3, , 941. Dam of 9 winners, including-NAVARONE c. by Irish River-FR ; . 8 wins, 3 to 6, 0, 325, Oak Tree Invitational S. [G1], Del Mar Invitational H. [G2] twice, Spence Bay H. [L] HOL, , 400 ; , Escondido H.-R DMR, , 325 ; -ncr, 3rd San Gabriel H. [G2], Escondido H.-R DMR, , 250 ; . Sire. MOON SPIRIT c. by Hatchet Man ; . 3 wins to 3, 4, 821, Lawrence Realization S.-G2, 2nd Rutgers H.-G2, Knickerbocker H.-G3. Sire. WAJNA f. by Nureyev ; . Black type winner, see above. Lapidist f. by Inverness Drive ; . Winner at 2, , 850, 3rd Sorrento S.-L. Producer. Flying Linnet. 2 wins at 4, , 080. Dam of 5 winners, including-Brookshire c. by Floating Reserve ; . 7 wins, 3 to 6, 3, 218, 3rd Sun Beau S. HAW, , 579 ; . 3rd dam * Moon Dancer II, by Never Give In. Winner at 2 and 3 in Ireland, highweighted filly at 2 on Free H., 2nd Tyros S., etc.; placed in 1 start at 2 in England, 2nd Princess Margaret S. Half-sister to COOL MOON 6, 111, sire ; , DONATO, Moon Shot. Dam of 6 winners, including Arctic Moon [G2] dam of THE BOURSE, 6, 098; FROZEN DINNER, 5, 143; Artic Alert, 3, 638; granddam of Arctic Sand, to 5, 2004 ; . Granddam of Infringe [G1] dam of ENGLAND'S ROSE, 5 wins, 6, 686, Chaposa Springs H. [G3], etc. ; , Ten Grand. Breeders' Cup nominated. KTDF and ketoprofen.
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