1. Bouroncle BA, Wiseman BK, Doan C A Leukemic reticuloendotheliosis. Blood 13: 609, 1958 Yam LT, Li CY, Lam KW: Tartrate-resistant acid phosphatase isoenzyme in the reticulumcells of leukemic reticuloendotheliosis. N Engl J Med 284: 357, 1971 Golomb HM, Catovsky D, Golde D W Hair cell leukemia: A clinical review of 71 cases. Ann Intern Med 89: 677, 1978 Golomb HM: The treatment of hairy cell leukemia. Blood 69: 979, 1987.

Alchemia establishes an Oncology Clinical Advisory Board Alchemia Limited today announced the establishment of a Clinical Advisory Board CAB ; comprising several international experts, with significant research and clinical experience in oncology to help guide the development of Alchemia's HyCAMP clinical program. The CAB will be chaired by Dr Peter Gibbs, who has been the Principal Investigator for the two successful HyCAMP trials run in Australia to date. It is intended that an Investigational New Drug IND ; application, to treat patients with colorectal cancer with HyCAMP and cetuximab Erbitux ; , will be filed with the US Food and Drug Administration FDA ; in the coming months. Alchemia's Clinical Advisory Board comprises: Dr Peter Gibbs Ludwig Institute, Royal Melbourne Hospital and Western Hospital, Australia ; Dr Mace Rothenberg Vanderbilt-Ingram Cancer Center, USA ; Dr Leonard Saltz Memorial Sloan-Kettering Cancer Centre, USA ; Dr Alan Venook University of California, USA ; Dr Tracey Brown Alchemia Oncology Pty Ltd and Monash University, Australia ; ENDS For further information: Dr Pete Smith Chief Executive Officer Alchemia Limited Tel: 0733400200 About Alchemia Limited - alchemia .au Alchemia Limited is a listed Australian biotechnology company ASX: ACL ; . The Company has particular expertise in chemistry, which it has applied to the discovery and development of human therapeutic products. Alchemia's antithrombotic drug, generic fondaparinux, is the Company's near term Alchemia's pipeline of assets are built on two platforms opportunity that targets the multi-billion dollar heparin-drug market and is expected to be generating revenues for the company in 2009. technologies: HyACT targeted cancer drug delivery ; and VASTTM drug discovery ; . Mr David Green Chief Financial Officer.

Most head and neck cancers occur in the oral cavity 43% ; followed by the pharynx 33% ; and the larynx 24% ; the estimated incidence of head and neck cancers in europe is around 140, 000 annually, with over 65, 000 deaths per year erbitux is approved in 15 countries as a monotherapy in patients with recurrent and or metastatic squamous cell carcinoma of the head and neck scchn ; who have failed prior chemotherapy, and in more than 60 countries for the combination with radiotherapy for the treatment of locally advanced scchn.

Erbitux revenue 1600 Table 4. Detection of Pre- and Post-Switch B Cells in MM Patients. In 2006, Worldwide Pharmaceuticals sales decreased 9% to , 861 million. U.S. Pharmaceuticals sales decreased 9% to , 417 million from , 190 million in 2005, primarily due to lower sales of Plavix resulting from the at-risk launch of generic clopidogrel bisulfate in August 2006 and loss of exclusivity of Pravachol offset by continued growth of Abilify, Erbitux, Reyataz, the Sustiva Franchise and Avapro Avalide, and sales of newer products including Orencia, Baraclude and Sprycel. In aggregate, estimated U.S. wholesaler inventory levels of the Company's key pharmaceutical products sold by the U.S. Pharmaceuticals business at the end of 2006 were approximately two and a half weeks. International Pharmaceuticals sales decreased 9% to , 444 million in 2006 from , 064 million in 2005, primarily due to a decline in Pravachol and TAXOL paclitaxel ; sales resulting from increased generic competition in Europe, partially offset by increased sales of newer products including Reyataz, Abilify and Baraclude. In 2005, Worldwide Pharmaceuticals sales decreased 2% to , 254 million. U.S. Pharmaceuticals sales in 2005 decreased 3% to , 190 million compared to , 446 million in 2004, primarily due to the continued impact of exclusivity losses of Paraplatin and the Glucophage Franchise and increased competition for Pravachol, partially offset by increased sales of growth drivers including Plavix, Abilify, Erbitux and Reyataz. In aggregate, estimated wholesaler inventory levels of the Company's key pharmaceutical 10. Erbitux survival rates In addition, the nsclc market is becoming increasingly crowded with molecular targeted therapy, with genentech and roche's avastin currently pursuing a first-line indication and erbitux in late-stage trials for second-line nsclc and ergotamine.

Erbitux toxicity Inventories-until february 12, 2004, all costs associated with the manufacturing of erbitux were included in research and development expenses when incurred. Erbitux is already approved for second- and third-line use in mcrc in the us and for third-line use in europe and erlotinib. Drug Solutions. Tariquidar Xenova Ltd., Slough, Bucks, UK ; for injection was dissolved in propylene glycol, 5% dextrose solution, and ethanol 4: 5: 1 ; initial concentration of 10 mg ml; subsequently, this was diluted with 5% dextrose solution to provide a concentration of 1.56 mg ml. For the flow-cytometry studies, tariquidar 3 mM ; was

Erbitux in combination with folfox-4 facilitates resection of metastases in 20 % of patients with initially unresectable metastases and ertapenem!

Two classes of agents are included in this category, various estrogen preparations, and a SERM. Use of HRT is waning due to the problems uncovered in the Women's Health Initiative. However use of the SERM, raloxifene, has been steady. All of the currently approved treatments of osteoporosis, including raloxifene, have clinical anti-fracture efficacy supporting their use. Pstein-Barr virus EBV ; has been associated with several germinal center GC ; derived B-cell lymphomas, such as endemic and sporadic Burkitt lymphoma, classical Hodgkin lymphoma cHL ; , and posttransplantation lymphoproliferative disease PTLD ; , inducing a typical latency I, II, and III gene expression program in these entities, respectively. As malignant cells in cHL and and eszopiclone. Setting. Randomized Phase III studies comparing gefitinib with docetaxel in terms of survival and quality of life are now ongoing. Additional studies are indicated to assess the possible role of gefitinib as maintenance therapy after chemotherapy for stage IV disease and after chemo radiotherapy for stage III disease. Paralleling the experience with gefitinib, erlotinib Tarceva ; demonstrated activity in the second-line setting, but first-line trials showed no advantage to erlotinib in conjunction with standard chemotherapy. There are unresolved issues in dosing with both erlotinib and gefitinib because they are given as a fixed dose despite individual differences in gastrointestinal absorption. In the second-line trials, response to erlotinib was correlated with the occurrence and severity of rash, an observation that provides a rationale for titrating the dose in individual patients to a level that causes detectable skin rash. A large randomized Phase III trial of erlotinib as second third-line therapy versus best supportive care is now completed, and the results of this trial will be important in clarifying whether the EGFR tyrosine kinase inhibitors can make a meaningful contribution in terms of survival improvement of lung cancer patients. Cetuximab C225, Erbitux ; is a monoclonal antibody that inhibits EGFR ligand binding, resulting in cell cycle arrest and increased expression of proapoptotic proteins. Preclinical studies indicated potential synergism between cetuximab and a number of chemotherapeutic agents, including cisplatin and paclitaxel. In fact, this synergy has been demonstrated clinically in colon cancer and head and neck cancer. Positive results have been reported in combination with chemotherapy. An ongoing study is now evaluating cetuximab as monotherapy in patients with NSCLC who have failed platinum-based chemotherapy. As with the EGFR tyrosine kinase inhibitors, molecular mechanisms predicting response to cetuximab therapy are currently not well understood. Some evidence suggests that anti-EGFR antibodies, which possess a different mechanism of action, may be more effective than the EGFR tyrosine kinase inhibitors when combined with chemotherapy. However, this is a very preliminary observation that has not yet been confirmed by clinical evidence. Vascular Endothelial Growth Factor-Targeted Agents. Bevacizumab Avastin ; is a monoclonal antibody directed against vascular endothelial growth factor. In a randomized Phase II trial in patients with advanced metastatic NSCLC, the addition of bevacizumab to standard carboplatin paclitaxel chemotherapy significantly increased the time to progression with a nonsignificant increase in response rate as well. Several Phase II trials investigating bevacizumab in combination with chemotherapy or with a targeted agent, such as erlotinib, are now under way. A large randomized study comparing standard chemotherapy with standard chemotherapy plus bevacizumab is being undertaken by the Eastern Cooperative Oncology Group. Ongoing trials will examine issues of optimal dosage and scheduling with chemotherapy and with other targeted therapies, as well as minimizing the risk of bleeding episodes that have been the most serious safety issue in the lung cancer trials. Folate-Targeted Agents. Pemetrexed Alimta ; is an antifolate agent with antitumor activity demonstrated in a number of solid tumors, including NSCLC. Supplementation with folic and erbitux.

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