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Table II. Mutations identified by sequence analysis of HPRT cDNA Type of mutation No. of unique mutationsa Non-smokers Not known Current Total and exsmokers smokers Single base pair substitution Start codon Missense Nonsense 39 2 ; 35 27b 3 ; 3 161b 15.
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Elderly patients aged between 66 and 75 years with previously untreated biopsy-proven HD were randomized between eight cycles of alternating COPP-ABVD arm A ; and eight cycles of BEACOPP baseline arm B ; within the HD9elderly stratum. Radiotherapy was given to initial bulky disease 30 Gy ; or residual tumor after chemotherapy 40 Gy ; . Patients with stage IIB and large mediastinal mass and or extranodal involvement and or massive spleen involvement and all patients in stage III and IV disease were eligible. Large mediastinal mass was defined as a tumor measuring one-third or more of the maximum intrathoracic diameter as determined by posterioranterior chest radiograph. Bulky disease was defined as a single lymph node involvement or a conglomerate mass of 5 cm any diameter. Stage of disease was defined according to the Ann Arbor Conference classification. Exclusion criteria included a positive human immunodeficiency HIV ; test, creatinine clearance below 60 ml min, serum bilirubin greater than 2 mg dl, concurrent infection, severe cardiac, pulmonary or cerebral dysfunction, white blood cell WBC ; count less than 3000 ml and platelet count less than 100 000 ml. Each patient provided written informed consent. Pretreatment evaluation involved medical history, physical examination, complete blood count, liver and renal functional tests, erythrocyte sedimentation rate, chest radiography, abdomen ultrasound, computed tomography CT ; of chest and abdomen, bone marrow biopsy and isotopic bone scan. In addition, lung function test and echocardiography were routinely carried out before treatment.

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1. OReilly RJ: Current developments in marrow transplantation. Transplant Proc 19: 92, 1987 Thomas ED, Buckner CD, Banaji M, Clift RA, Fefer A, Fluornoy N, Goodell BW, Hickman RO, Lerner KG, Neiman PE, Sale GE, Sanders JE, Singer J, Stevens M, Storb R, Weiden PL: One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood.

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Area Clergy who attended the health fair and luncheon at IMH were: Front row left to right ; : Mel Meyer, St. John's Lutheran, rural Milford; Harold Grafe, St. Peter's Lutheran, Crescent City; Van Haas, Sheldon Church of Christ, Sheldon; Neil Larimore, Milford Christian Church, Milford; and Garry Steffe, First Assembly of God, Watseka. Back row left to right ; : Darrell McDaniel, First Christian Church, Hoopeston; Paul Copeland, First United Methodist Church, Watseka; Larry Jurgeson, Faith Lutheran, Watseka; David Todd, First Christian Church, Watseka; Tom McCann, Iroquois Memorial Hospice Chaplain; Terry Horn, Donovan Church of Christ, Donovan; Jim Harkins, Life, Gilman; Jim Small, Onarga Christian Church, Onarga; Father Lee Ryan, Watseka and Crescent City Catholic; Jon Sharp, Christian Bible, Cissna Park.

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Figure 8. Electrophoretic pattern of DNA extracted from myocardial tissue A ; and isolated left ventricular myocytes B ; obtained from sham-operated SO ; and CAN nontransgenic littermates L ; and transgenic mice T ; . MW, molecular weight markers. In panel A, DNA diffusion is apparent in CAN nontransgenic littermates, whereas in panel B mononucleosomes and oligonucleosomes are visible in CAN nontransgenic and transgenic mice.

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