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Notes: 1. At each Cycle, 1 day prior to treatment the following investigations are required FBC U&Es LFTs CEA 2. Following a toxicity assessment treatment may be ordered in accordance with current protocol guidelines. Patients reporting adverse toxicity i.e. grade 2 toxicity, unexpected toxicities, adverse events, those patients experiencing a neutropenic episode since the previous cycle will be scheduled to see medical staff within the chemotherapy clinic for dose review. If acceptable blood parameters are not met treatment will be deferred in accordance with current protocol guidelines. Dose reductions will ONLY be made following Consultant review. A CEA marker rise of 20% from pre chemotherapy baseline will require a Consultant review 3. Dose Modifications for Age & Renal Impairment All patients over 70 years of age will have their starting doses of capecitabine reduced to 1000mg m2 twice daily, if their creatinine clearance is 50ml min DATE OF ISSUE: 31.01.07 VERSION 3 REVIEWED BY C D AUTHORISED BY Dr P Chakraborti PAGE 1 of 4 REVIEW DATE: 31.01.09.
After the AGM by Diana Cooper During the AGM held on 10th November 2005 there was a lively discussion about the future residency of Badan Warisan Malaysia. Concern was expressed about the rapid development surrounding No2 Jalan Stonor and the potential impact this could have on the tenure of the site. Many members felt strongly about remaining at the present location. At the Council Members meeting held on 7th December these issues were discussed and in response it was decided to appoint an ad hoc committee to explore these topics. Members of this committee are Christopher Boyd, Datuk Abdul Rahim Abdullah, Datuk Haji Ismail Adam and Dr. Chandran Jeshurun. Their objective will be to investigate the security of tenure of the present premises and consideration of an alternative long-term home for the Secretariat. Members will be updated of any news or developments. Resource Centre by Puan Sri Susan Jalaluddin As members are fully aware, the Resource Centre has grown beyond expectations over the years and now holds a great deal of very valuable and most useful material. This growth has demanded better storage, both to keep the material safe and to enable full access to the information, both for external researchers and Badan Warisan Malaysia itself. To meet this demand, extensive renovations have been made to the annex at the back of the main Badan building. The toilets and shower room have been renovated for more comfortable use and the two adjacent rooms remodelled for the Resource Centre. These two rooms will be used to store the Resource Centre materials systematically in a safe environment. The Centre will now be a fully closed system and all researchers will have access only to the materials they have previously requested. These materials will be made available to them in the Reading Room, the previous Resource Centre. There have been some wonderful donors who have facilitated these renovations and BADAN WARISAN MALAYSIA is most grateful for their generosity. Others have donated books, photographs and various other useful materials for the Centre and these are always gratefully received. We are always looking for suitable additions to the Resource Centre and ask members to inform us, in writing, of any publications they consider appropriate. Staff Matters We are delighted to announce that Ms Nurzaifullah binti Mansor will be joining Badan Warisan Malaysia as Information and Library Officer from 13 March 2006. Ms Intan Syaheeda will take on the position of Project Officer, dedicating her time to our special projects e.g. Mubin Sheppard Memorial Prize, National Heritage Awards, Rumah Penghulu Abu Seman and others.
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The fourth Thalassaemia Congress, organised by the Iranian Thalassaemia Society, provided an important opportunity to assess the status of the disease in Iran. The event was divided into three panels focused on prevention and diagnosis, treatment, and the effects of thalassaemia. Three members of the Iranian Thalassaemia Society ITS ; board addressed the Congress: Honorary ITS President Dr M. Izadyar spoke on `Yesterday, today and the future of thalassaemia in Iran'; ITS President Dr M Hadipour considered `Questions from the specialists'; and ITS Vice-President Dr H. Hoorfar discussed `Pregnancy in thalassaemia major', including a case study. In addition to insightful talks and discussion, Congress participants identified key issues facing the thalassaemia community in Iran: 1. Recent years have seen the emergence of specialist research centres at leading universities, capable of carrying out cutting-edge laboratory work in the field of thalassaemia. While such developments are to be welcomed, work now needs to be directed towards the towns and provinces where the incidence of thalassaemia is high and increasing. 2. The Ministry of Health and Medical Education to establish a medical insurance scheme to support families undergoing pre-pregnancy genetic testing. 3. Counselling to become more widely available, particularly targeting couples who married before the national thalassaemia prevention plan was active. 4. The Ministries of Health and Medical Education to reinforce their efforts regarding the prevention of new affected births. 5. New bone marrow transplant centres to be established. 6. The wider availability of the chelation drug desferoxamin, as well as the existing and new oral drugs. 7. The establishment of new techniques such as MRI, T2 * and HIC ; to assess more accurately the iron load. 8. Address social integration issues facing patients, including education, marriage and employment. 9. Establishing standard, appropriately staffed thalassaemia treatment centres across the country which will undertake to improve blood safety and adequacy, the prevention and treatment of osteoporosis, the diagnosis and treatment of transfusion-depended hepatitis particularly in terms of securing essential drugs such as pegylated interferon and all issues that currently pose great challenges to health professionals working in the field of Thalassaemia.
For some people in the San Joaquin Valley, Dr. Muhammad Sheikh's research could mean the difference between life and death. Sheikh is chief of gastroenterology and hepatology with UCSF Fresno Medical Education Program and University Medical Center in Fresno. As part of a national study, more than 540 adults are enrolled in hepatitis C Latino study, designed to compare hepatitis C treatment response rates of two FDA-approved medications Pegasys peginterferon alfa-2a ; plus Copegus ribavirin, USP ; in Latinos and non-Latino Caucasians. "This large multi-center study will be an important milestone in understanding the safety and efficacy of current hepatitis C therapy in Latino populations, " Sheikh said. "We believe our center is providing a substantial service to the community not only in treating hepatitis C, but also as a source of information and support." As with any study there are risks. However, hepatitis C patient Billy Tucker said the clinical trial might have saved his life.
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Like HL60 cells, efficiently transported DHA, the oxidized form of vitamin C, but not AA Fig. 1B ; . Incubation of U266 cells with 50, 100 and 250 M DHA increased the intracellular concentration of vitamin C to approximately 1, 2 and 4 mM, respectively Fig. 1B ; . Incubation with 1 and 1.5 mM DHA for 1 hour resulted in intracellular AA concentrations of approximately 9 and 10 mM, respectively. To confirm that U266 cells transport DHA via the facilitative glucose transporters, cells were incubated for 60 min with cytochalasin B a glucose transporter inhibitor ; and then 100 M and capsicum.
Do you find any common side effects from either LAR, short term Sandostatin or Interferon? Common side effects can be nodules forming at injection site with irritation. May also experience griping abdominal discomfort, worsening diarrhoea related to Octreotide or Sandostatin as the pancreatic enzymes don't work as well. Longer term effects 50% of patients on Octreotide or Lanreotide will develop gallstones, out of which only 10% will become symptomatic. Now suggesting to surgeons that anyone having an operation for a NET, they may consider taking out the gallbladder at the time of surgery, so in future years they may save another operation to remove it. More side effects with Interferon similar to flu symptoms and depression which can be quite debilitating. Checks required on blood count as white count, which fights infection, can be suppressed, a number of patients can become anaemic and problems may occur with clotting. Also check for thyroid gland problems regularly, problems with joints, and intolerance of Interferon. Do you think it could cause diabetes and other diseases? It is possible not quite so recognised with Interferon. Are there any results from the Sandostatin questionnaires sent out? Still awaiting outcome. The presentation of the pack was changed. Now finding there is a gap between injections. Shouldn't be any change in the chemical formulation and the treatment effect. Nurses seem to prefer the new package. With long-term chemotherapy do you have any data on length of treatments, for example I have chemo for 5 days, is there any reason why it couldn't be 4 or days? Depends on which chemotherapy agent is used. Strategies are changing appears to be benefit from giving certain agents on a more consistent basis rather than the oldfashioned bolus basis, where they'd have the one bolus and return the next month. With the 5-fluorouracil agent, which used to be given as a bolus then an infusion over a week, there's now an oral agent, some patients taking daily or for 7 days in a month. Appears to be more benefit if taken over a period of a number of days, but it is agent specific. National trial being undertaken with NET patients looking at chemotherapy, where we used to give the intravenous 5-FU as a bolus and then switching it over to the oral capecitabine preparation. One of the symptoms on Martyn's presentation was pellagra 5% ; , what is the approach to manage it? Probably under-diagnosed. Many patients with carcinoid syndrome will have dry skin and irritation relating to Vitamin B and niacin deficiency. Many of my patients are on a strong compound Vitamin B supplement, which has niacin or nicotinomide supplement, and with an appropriate amount pellagra should be overcome. My wife gets a reaction to taking the niacin, is there anything that can be done for that? There are various brands of nicotinomide that can be tried. Some patients have been given an intravenous supplement, so there are some ways around giving it. Is it advisable for everyone who has carcinoid to be on Vitamin B? If you have the carcinoid syndrome, then there are definite benefits to being on Vitamin B as the body does become deplete because the tumour cells eat up the Vitamin B which then results in conditions such as pellagra. Also think there is also a benefit of having a broad spectrum diet in terms of Vitamins A, C and E because they are scavengers in terms of mopping up inflammation as well. How big is the support group now? There are now just over 200 on the database who were all notified of the meeting, together with fliers to specialist groups.
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Basel, 15 June 2000 Roche's novel oral treatment for colorectal cancer approved in New Zealand - effective oral chemotherapy Roche announced today that Xeloda capecitabine ; , an oral chemotherapy for the treatment of metastatic breast cancer, has received its first approval for metastatic colorectal cancer. The New Zealand Ministry of Health has approved the drug for first-line use in patients with colorectal cancer that has spread to other organs or grown inoperable beyond the colon wall. "The approval of Xeloda for metastatic colorectal cancer validates the extensive clinical testing we have done in patients around the world, " said Dr. Peter Teuber, Xeloda Life Cycle Leader at Roche. "Xeloda has been shown to shrink tumors better than standard therapy, while providing a comparable survival benefit and an improved safety profile. Also, because it is taken as a tablet, Xeloda therapy reduces the need for patients to travel to a clinic or hospital for intravenous treatment." According to the World Health Organization, in 1990 the last year that statistics are available more than 780, 000 people were diagnosed with colorectal cancer, and more than 435, 000 people died that year from the disease. The New Zealand approval was based on the results of two large multi-centre phase III clinical trials, which involved a total of 1, 200 patients at 120 hospitals and cancer centers worldwide. Xeloda was administered at twice daily 1250 mg sqm, for two weeks followed by a one-week rest period and repeated in three week cycles. The results indicate that Xeloda has at least equivalent efficacy to a current standard of care for metastatic colorectal cancer, fluorouracil 5-FU ; and leucovorin, known as the Mayo Clinic regimen. The drug showed superior tumor shrinkage to the Mayo regimen and an at least equivalent time to progression and survival benefit. Xeloda, manufactured by Roche, is the first oral drug that works through a unique enzymatic activation to convert Xeloda to the potent cancer-fighting substance 5-FU actually within the cancer cells themselves. Because the enzyme that activates Xeloda is found at high levels in cancer cells, Xeloda is preferentially activated to 5-FU in tumor tissue. 5-FU itself is a standard therapy for colorectal cancer, but until now could only be administered intravenously. This unique mechanism of action of Xeloda is important in delivering the increased tumor shrinkage and improved safety profile compared to standard 5-FU intravenous therapy. Xeloda is approved in 34 countries for patients with metastatic breast cancer who have not responded to or are no longer responding to chemotherapy with both Taxol paclitaxel ; and an anthracycline-containing chemotherapy regimen such as one containing Adriamycin doxorubicin ; . Xeloda is under regulatory review for metastatic colorectal cancer in over 50 countries, including the United States, the European Union, Canada and Switzerland. Headquartered in Basel, Switzerland, Roche is one of the world's leading research-oriented healthcare groups in the fields of pharmaceuticals, diagnostics and vitamins. Roche's innovative products and services address prevention, diagnosis and treatment of diseases, thus enhancing people's well-being and quality of life and carbachol.
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Therapy and in combination therpay relapsers: final results abstr ; . Gastroenterology 2003; 124 Suppl 1: A714 Jonas MM. Children with hepatitis C. Hepatology 2002; 36: S173-S178 Wirth S, Lang T, Gehring S, Gerner P. Recombinant alfainterferon plus ribavirin therapy in children and adolescents with chronic hepatitis C. Hepatology 2002; 36: 1280-1284 Alberti A, Benvegnu L. Management of hepatitis C. J Hepatol 2003; 38 Suppl 1: S104-S118 Jacobson KR, Murray K, Zellos A, Schwarz KB. An analysis of published trials of interferon monotherapy in children with chronic hepatitis C. J Pediatr Gastroenterol Nutr 2002; 34: 52-58 Gonzalez-Peralta RP, Kelly DA, Haber B, Molleston J, Murray KF, Jonas MM, Shelton M, Mieli-Vergani G, Lurie Y, Martin S, Lang T, Baczkowski A, Geffner M, Gupta S, Laughlin M. Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics. Hepatology 2005; 42: 1010-1018 EASL International Consensus Conference on hepatitis C. Paris, 26-27 February 1999. Consensus statement. J Hepatol 1999; 31 Suppl 1: 3-8 Zeuzem S, Diago M, Gane E, Reddy KR, Pockros P, Prati D, Shiffman M, Farci P, Gitlin N, O'Brien CB, Lamour F, Lardelli P. Peginterferon alfa-2a 40 kilodaltons ; and ribavirin in patients with chronic hepatitis C and normal aminotransferase levels. Gastroenterology 2004; 127: 1724-1732 Edlin BR. Prevention and treatment of hepatitis C in injection drug users. Hepatology 2002; 36: S210-S219 Edlin BR, Seal KH, Lorvick J, Kral AH, Ciccarone DH, Moore LD, Lo B. Is it justifiable to withhold treatment for hepatitis C from illicit-drug users? N Engl J Med 2001; 345: 211-215 Heathcote J, Main J. Treatment of hepatitis C. J Viral Hepat 2005; 12: 223-235 Deyton LR, Walker RE, Kovacs JA, Herpin B, Parker M, Masur H, Fauci AS, Lane HC. Reversible cardiac dysfunction associated with interferon alfa therapy in AIDS patients with Kaposi's sarcoma. N Engl J Med 1989; 321: 1246-1249 Angulo MP, Navajas A, Galdeano JM, Astigarraga I, Fernandez-Teijeiro A. Reversible cardiomyopathy secondary to alpha-interferon in an infant. Pediatr Cardiol 1999; 20: 293-294 Forns X, Garcia-Retortillo M, Serrano T, Feliu A, Suarez F, de la Mata M, Garcia-Valdecasas JC, Navasa M, Rimola A, Rodes J. Antiviral therapy of patients with decompensated cirrhosis to prevent recurrence of hepatitis C after liver transplantation. J Hepatol 2003; 39: 389-396 Gentil MA, Rocha JL, Rodriguez-Algarra G, Pereira P, Lopez R, Bernal G, Munoz J, Naranjo M, Mateos J. Impaired kidney transplant survival in patients with antibodies to hepatitis C virus. Nephrol Dial Transplant 1999; 14: 2455-2460 Strader DB. Understudied populations with hepatitis C. Hepatology 2002; 36: S226-S236 Russo MW, Goldsweig CD, Jacobson IM, Brown RS Jr. Interferon monotherapy for dialysis patients with chronic hepatitis C: an analysis of the literature on efficacy and safety. J Gastroenterol 2003; 98: 1610-1615 Fabrizi F, Poordad FF, Martin P. Hepatitis C infection and the patient with end-stage renal disease. Hepatology 2002; 36: 3-10 Bruchfeld A, Lindahl K, Stahle L, Soderberg M, Schvarcz R. Interferon and ribavirin treatment in patients with hepatitis C-associated renal disease and renal insufficiency. Nephrol Dial Transplant 2003; 18: 1573-1580 Gupta SK, Pittenger AL, Swan SK, Marbury TC, Tobillo E, Batra V, Sack M, Glue P, Jacobs S, Affrime M. Single-dose pharmacokinetics and safety of pegylated interferon-alpha2b in patients with chronic renal dysfunction. J Clin Pharmacol 2002; 42: 1109-1115 Dienstag JL, McHutchison JG. American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology 2006; 130: 231-264; quiz 214-217 Fried MW. Side effects of therapy of hepatitis C and their management. Hepatology 2002; 36: S237-S244 85.
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You are Needed! No experience necessary, just your willing heart and your smiling face. Ushers are needed for the months of January and February 2008, if you are interested in ministering in this capacity please see the sign up sheet outside the church office. Quaint Quilters will resume weekly meetings after January 1st and carbenicillin.
Katzmarzyk PT Queen's Institute of Population & Public Health, Queen's University, Kingston, Canada Corresponding Author: katzmarz post.queensu Funding Source: Sanofi-Aventis Canada Inc. Background: Obesity has become a major public health issue over the last 2 decades, as it is known to be strongly related to hypertension, heart disease, stroke, diabetes, and several cancers. Also, the presence of cardiometabolic risk factors CMRF ; is suspected to further increase the risk of cardiac and metabolic morbidity and mortality. Objective: To assess the prevalence and incidence of obesity and CMRF in Canada. Methods: This was done through a literature search and the Canadian Community Health Survey CCHS ; and the Canadian Heart Health Survey CHHS ; analysis. Results: The prevalence of overweight BMI 25.0-29.9 2 kg m ; in Canada in 2004 was found to be 42% in males and 30.2% in females while the prevalence of 2 obesity BMI 30 kg m ; was 22.9% in males and 23.2% in females. Among men and women who had a normal weight in 1994 95, 38% and 28%, respectively, became overweight by 2002 03. Of those who were overweight in 1994 95, 20% and 28%, respectively, became obese by 2002 03. The most recent national data on CMRF is the Canadian Heart Health Surveys 1986-92 ; . The overall prevalence of people CMRF was 17.5% in men and 14.7% in women 1986-92 CHHS ; . Prevalence increases with advancing age, from a low of 3-8% in 20-29 y olds to a high of 30-39% in 70-74 y olds. Among ethnic groups, CMRF appears to be more prevalent among Aboriginal groups. Although temporal trends cannot be established at this point, the age-adjusted prevalence of CMRF increased from 24.1% in 1988-94 to 27.0% in 1999-2000 in the United States. Conclusions: The combined influence of obesity and metabolic dysregulation remains a public health burden requiring effective prevention and treatments. These prevalences are likely to be underestimated and more recent surveys are required. Keywords: Obesity, metabolic syndrome, epidemiology.
| Capecitabine herceptinResearch that have significantly improved signal generation and detection capability and smaller sample size requirements. Atomic force microscopy AFM ; , a well-established tool used to measure nanoscale surface features in semiconductors, is now able to measure forces in biological processes and to initiate intracellular signalling. Continued advances in instrumentation and techniques for example, by coating the AFM tip with an antibody or small organic molecule ; have resulted in an ever-increasing number of novel applications, with more expected to emerge in the future. AFM has been used to compare the effects of different molecules on inhibiting the formation of insoluble plaques associated with Alzheimer's, and in cancer research to study the timing at which cancer cells decrease in height and volume when exposed to an apoptosis-inducing agent. A new technique called force volume imaging or affinity mapping the AFM-coated tip creates a force curve as it approaches and retracts from different positions across a cell ; can identify the distribution of target molecules on the cell surface or study changes induced by drugs on the mechanical properties of cell membranes. Other applications of AFM include imaging living cell features that traditional optical methods have been unable to capture, such as the detailed structure of neuronal processes, or monitoring intracellular calcium signalling32 to determine how osteoblasts bone forming cells ; sense and respond to strain and how mechanical forces exercise ; can affect their growth. In the area of screening and lead optimization, magnetic nanoparticles combined with magnetic resonance imaging have been developed for rapid screens of telomerase activity for target identification in cancer. Nanoscale cantilevers can detect the presence of a particular genetic sequence or other molecules for target validation, ADMET screening, and metabolism studies binding with a complementary molecule induces a bending stress that can be measured using laser interferometry ; . Other examples include a nanofluidic system for crystallizing proteins that cannot be grown with conventional technologies; DNA scaffolds or cages that organize proteins for crystallography experiments; nanowire devices that analyze the specific binding of small molecules to proteins for drug discovery and screening; and gold nanoparticles coated with oligonucleotides nano bar codes ; for ultrasensitive detection of biomarkers. Microarrays and microfluidic chips will be replaced by the next-generation miniaturization technologies, nanoarrays and nanofluidics. Nanoarrays are ultra-high-density gene chips with 100, 000 spots of DNA in the area occupied by a single spot in conventional microarrays; this level of ultra-miniaturization will require additional developments in dip-pen nanolithography as well as novel signal processing techniques that can discriminate a weak signal from background noise. Also in development are higher density protein arrays. Microfluidic chip platforms the so-called lab-on-a-chip ; integrate a chemistry lab on a small substrate using micro-electromechanical systems MEMS ; to manipulate and analyze liquid volumes. The sensitivity can be enhanced by creating nano-electro-mechanical systems NEMS ; and structured surfaces and channels. Applications can be expanded to include analyzing individual molecules such as target oligonucleotides, sequencing strands of DNA and RNA for example, by correlating changes in the electric current that flows through the pore as the single-strand DNA molecule passes through the opening ; , and increasing the number of screening experiments. Edmontonbased Micralyne is a leading microfabrication company supplying MEMS-based products such as biosensors, chips for sequencing, and imbedded drug delivery devices to a variety of industries and carboplatin.
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ABSTRACT: To investigate the possible role of testicular orphan receptors TR ; TR2, TR3, and TR4 in the process of germ cell apoptosis in the heat-treated testis of monkey, we have examined the spatiotemporal expression of the 3 TR mRNAs in relation to p53 mRNA levels in the monkey testis by in situ hybridization and reverse transcription polymerase chain reaction techniques. The results showed that TR2 mRNA was confined to spermatocytes; TR4 and TR3 mRNAs were expressed in both spermatocytes and spermatids. The heat treatment did not change TR2 mRNA level but significantly reduced TR4 mRNA expression in spermatocytes on days 3 and 8 after the heat treatment. TR3 mRNA expression was affected by the heat treatment in a time-dependent manner, with the lowest level on day 30 after the heat shock. Low to moderate signal for p53 mRNA and carmustine
| 10: 40 a.m. Research and Development of High Temperature Light Water Cooled Reactor Operating at Supercritical-pressure in Japan, Y. Oka Univ of Tokyo-Japan ; , K. Yamada Toshiba-Japan ; 11: 00 a.m. Research of Supercritical Pressure Water Cooled Reactor in Korea, Y.Y. Bae, H.K. Joo, J.S. Jang, Y.H. Jeong, J.H. Song, H.Y. Yoon KAERI-USA ; , J.Y. Yoo Seoul National Univ-Korea ; PRA and Risk-informed Decision Making: Methodology--II, Session Organizers and Co-Chairs: Robert E. Gamble GE Nuclear Energy-USA ; , Nam Dinh UC Santa Barbara-USA ; Panel Oval Mezzanine Level ; 10: 00 a.m. Reliability Methods for Passive Systems, M. Marqus, J.F. Pignatel CEA DER, Cadarache-France ; , F. D'Auria Univ of Pisa-Italy ; , L. Burgazzi ENEA-Italy ; , C. Mller GRS-Germany ; , R. Bolado-Lavin, C. Kirchsteiger EC-JRC IE, Petten-The Netherlands ; , V. La Lumia TECHNICATOME ; , I. Ivanov, B. Kalchev Technical.
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A resolution such as is referred to in paragraph 1 ; c ; shall, unless it is sooner revoked by a resolution of the Assembly, ceased to be in force at the expiration of two years beginning on th e date on which it was passed 4 ; or such shorter period as may be specified therein, but with out prejudice to the passing of another resolution by the Assembly in the manner prescribed by that paragraph at or before the end of that period. where any person is lawfully detained by virtue of such a provision as is referred to in article 150 2 ; , or the movement or residence within Guyana of any person or any per son's right to leave Guyana is otherwise than by order of a court ; lawfully restricted by virtue of such a provision as 1 ; aforesaid, his case shall be reviewed by a tribunal established for the purposes of this article not later than three months from the commencement of the detention or restriction and thereafter not later that six months from the date on which his case was last reviewed as aforesaid. On any review by a tribunal in pursuance of the preceding paragraph of the case of any person the tribunal may make recommendations concerning the necessity or expedience of continuing the dete ntion or 2 ; restriction to the authority by whom it was ordered but, unless it is otherwise provided by laws, that authority shall not be obliged to act in accordance with any such recommendation. A tribunal established for the purpose of this article shall be so established by law and constituted in such manner as to secure appointed by the 3 ; Chancellor from among persons entitled to prac tise in Guyana as attorneyat-law. Except in proceedings commenced before the expiration of a period of six months from the commencement of this Constitution, with respect to a law made under the Guyana Indep endence Order 166 and the 1 ; Constitution annexed thereto, nothing contained in or done under the authority of any written law shall be held to be inconsistent with or in contravention of any provision of articles 138 to 149 inclusive ; to the extent that th e law in question is a law in this article referred to as "an existing law" ; that had effect as part of the law of Guyana immediately before the a ; commencement of this Constitution, and has continued to have effect as part of the law of Guyana at all times since that day; b ; repeals and re-enacts an existing law without alteration; or and capecitabine.
Library news From his Cage the Librarian Extemporizes on the Centenary. The best introduction for anyone interested in the history of the Botany School is Max Walters' The Shaping of Cambridge Botany. This covers everyone from the early herbalists onwards, including my bte noire Charles Cardale Babington -- the melancholy dude with the beard whose portrait hangs on the centre back wall of the tearoom see above Ed ; . Babington wrote detailed floras of Cambridgeshire and also Notes on British Brambles Rubus ; . Only last week I discovered that someone who studies brambles is called a batologist. from the Greek `batos' for bramble. And you thought a batologist studied vampires or cricketers or psychiatric nurses. Other notable departmental batologists include W.H. Mills a chemist who apparently sang hymns while batologising in our herbarium ; and of course our very own Peter Sell who, along with Gina, is completing his Flora of Great Britain. The herbarium here contains the most comprehensive collection of Rubus samples in Europe. NB. Battology with two ts means needless repetition in speaking and writing, so I'll move ahead swiftly. Babington was The Most Boring Man Who Ever Lived. Film buffs may remember Madonna's comment on Rosanna Arquette's diary in Desperately Seeking Susan, "This must be in code. Nobody's life could be this boring." Babington's journals are currently housed at the UL but after many years of hermeneutic study I have discovered many hidden references to opium and flagellation. When the new Herbarium is completed we will regain our priceless collection of herbals and early historical works. At present there is only a small selection in our Library, but we have retained the Grete Herbal of MD XXIX -- delving into Stearn's Botanical Latin and caverject.
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