After re-treatment. Therefore, brain necrosis was caused not by the first but the second irradiation. More recently, manufacturers of diet soft drinks have shown interest, opening a large, unanticipated market. Although the cost differential between high- intensity sweeteners and tagatose on a sweetness-to-sweetness basis ; seemed to preclude using tagatose in soft drinks, this has turned out not to be the case. Arla Foods discovered 28 a synergism between tagatose and high- intensity sweeteners in which less than 1% of tagatose is required to effect a substantially improved flavor and mouthfeel of diet sodas. This has changed the cost paradigm. Applying tagatose in this way may overcome the objections consumers have about poor taste, which are believed responsible for the flattened growth curve of diet sodas over recent years. Health foods Arla Foods also discovered 29 that tagatose has prebiotic properties that improve digestion. Long appreciated in Europe and Asia, prebiotic properties are of growing interest in the United States. Tagatose selects for more favorable or benign microbial flora in the intestine and against potentially pathogenic organisms such as Escherichia coli. Moreove r, tests have shown that ingestion of tagatose produces larger amounts of desirable short-chain fatty acids, in particular butyrate, than are produced by a normal diet. The beneficial effects of butyrate, including a defense against colon cancer, have been cited in the literature 30 . More recently, Arla Foods found that tagatose can improve the taste of health bars 31 while adding to the health benefits of this increasingly popular part of many health and diet regimens. Other beneficial health uses for tagatose could support a variety of dietary supplements. These include use of tagatose to make low-glycemic breads, its antihyperglycemic properties, and its safe tolerance by diabetics.
We thank Dr. Krohn for his thoughtful comments. The mechanism for the desaturation seen in some elite athletes is likely to be related to the high cardiac output leaving insufficient time for equilibration of oxygen tensions between the alveolus and alveolar capillaries. Oxyhemoglobin desaturation in response to maximal exercise is a very unusual finding in normal adults performing exercise near sea level 1 ; . Cardiac output at peak exercise is low in patients with primary pulmonary hypertension PPH ; . Desaturation is unlikely to be due to the same mechanism as that occurring in elite athletes. Arterial oxyhemoglobin desaturation is not a feature of circulatory diseases or deconditioning Peter Hasbrook, of East Lansing, has been elected to the Michigan Parkinson Foundation Board of Directors. He comes with an impressive background with IBM, as Director and President of various computer concerns including COMPULINK Computer Systems, Ingham Regional Education Computer Center and Comsysco, and as Associate Director and Executive Director of the Michigan Catholic Conference. Peter, who has been diagnosed with PD, has been very active with the Greater Lansing Support Group and has taken a leadership role on MPF's Advocacy Committee. Judge Gail and Richard McKnight were elected to the Board of Directors along with Peter. Gail has been District Court Judge in Westland since 1985, and Dick, who was in private law practice for 30 years, is Wayne County Family Court Referee, handling cases of child abuse and neglect. Recently, Gail assumed the role of Facilitator of the Ann Arbor Support Group. They bring to the Board of Directors not only direct experience with PD with Richard's diagnosis, but also a rich background in many community organizations.

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